Connexin 30 is expressed in the mouse sino-atrial node and modulates heart rate

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Connexin 30 is expressed in the mouse sino-atrial node and modulates heart rate.

AIMS This study aimed at characterizing expression and the functional role of the Gjb6 gene, encoding for connexin 30 (Cx30) protein, in the adult mouse heart. METHODS AND RESULTS The expression of the Gjb6 gene in the mouse heart was investigated by RT-PCR and sequencing of amplified cDNA fragments. The sites of Gjb6 expression were identified in the adult heart using transgenic mice with re...

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Atrial tachycardia secondary to sino-atrial node reentry.

In one patient reprodncibk episodes of sMal tachyear(200 msec, control; 70 msec, atropine) and sustained dia conld be elicited via programmed atrial premature atrial tachycardia no longer could be elicited. These dcpoluizations. Evllodion of the elechpphysiologic studies mpport the concept that h a t t i a l reciprocation shldks suggested that the most tikely mechanism was can be a mechanism re...

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Responses of the sino-atrial node to change in pressure in the sinus node artery.

The sino-atrial node area was perfused selectively through the right atrial artery in 76 dogs. The relationship between changes in the blood pressure in this artery and sinus node rhythmicity was studied in 56 hearts in which the major blood supply to the sinus node artery came from the right atrial artery. A reciprocal relation was observed between changes of blood pressure in the sinus node a...

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Sino-atrial reciprocation in the isolated rabbit heart.

Reciprocal beats between sinus node and atrium were studied in isolated rabbit heart tissue by microelectrode techniques. Early premature atrial responses which entered the sinus node frequently emerged to re-excite the atrium as "echoes." When the premature atrial beats discharged some but not all nodal areas, the atrial echoes, in turn, appeared to re-enter the sinus node. Repetitive reciproc...

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Pacemaker mechanism of porcine sino-atrial node cells.

In cardiac sino-atrial node (SAN) cells, time- and voltage-dependent changes in the gating of various ionic currents provide spontaneous, stable and repetitive firing of action potentials. To address the ionic nature of the species-dependent heart rate, action potentials and membrane currents were recorded in single cells dissociated from the porcine SAN, and compared with those from SAN cells ...

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ژورنال

عنوان ژورنال: Cardiovascular Research

سال: 2009

ISSN: 1755-3245,0008-6363

DOI: 10.1093/cvr/cvp280